Foramen ovale is a hole in the wall between the right and left upper chambers of the heart. When a baby enters the world and takes its first breath, foramen ovale closes. If foramen ovale remains open after birth, then patent foramen ovale occurs. Generally, about 25 percent of normal people have patent foramen ovale and there is no any particular influence on people normally. People often know they have patent foramen ovale when they test other related diseases.
Patent foramen ovale refers to the opening of foramen ovale after birth. There are still no clear causes of it, but recently scholars find that unexplained strokes and migraines with aura might be associated with patent foramen ovale