Chronic granulomatous disease (CGD) is a disorder that damages the immune system. It makes your body susceptible to infections caused by particular fungi and bacteria. It causes granulomas, which are collections of immune cells that form at sites of inflammation or infection. Hence, chronic granulomatosis can cause splenic abscess. You can have an ultrasound of the spleen.
What granulomatous diseases? Granulomatous disease is a broad category of conditions that are most commonly caused by various infections. These infections would stimulate your macrophages, which are normally found in the liver, spleen, and connective tissues of the body. So most granulomatous diseases would cause liver and spleen enlargement.