Creatinine is a chemical waste product that's produced by your muscle metabolism and to a smaller extent by eating meat. Healthy kidneys filter creatinine and other waste products from your blood. The filtered waste products leave your body in your urine.
If your kidneys aren't functioning properly, an increased level of creatinine may accumulate in your blood. As your creatinine has increased to 400, it is very urgent and critical time for you. As your kidney condition is progressive, it can develop into two opposite directions. With an effective treatment in time, your renal function can be improved and creatinine level will decline. Otherwise, you will have to start dialysis if your creatinine level increases further.
Mean corpuscular volume (MCV), also known as mean cell volume, is an important number listed on a complete blood count (CBC) that can help diagnose different types of anemia as well as other health conditions. The MCV is a value that describes the average size of red blood cells (erythrocytes) in a blood sample. While the MCV can provide important information, it is not used alone—it is interpreted along with blood counts and other red blood cell indices such as mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW) to narrow diagnoses. A high MCV indicates larger RBCs and is called macrocytosis. The MCV can be a helpful test even when the red blood cell count and other tests are normal, especially in the setting of kidney disease.