I suffered from blepharitis for a couple years. I tried everything. I had a wonderful eye doctor who assured me that we would tackle the problem. Apparently, I was the worst case he had ever treated. What did work was a very strong eye infection antibiotic called Azasite Opthamalic. I believe in my case it was considered to be an "off-label prescription" and I used it for a much longer term. One round of this medication lasts six weeks, and my doctor extended that to two rounds. Taking the medicine was a mixed blessing, as IT DID ULTIMATELY WORK. But, applying the drops was VERY painful - like dripping acid on my eyeballs. However, once the burning subsided, my eyes calmed down and it really controlled the itching. I must emphasize that I was a really bad case. By the time I found my great doctor, my eyelids were scabbed and peeling, making it painful just to blink, much less close my eyes and get a good nights sleep. Azasite, Azasite, Azasite!