With the continuous improvement of living standards and changes in diet and lifestyle of modern people, the incidence of hyperuricemia and gout has increased significantly. Among them, alcoholism, high purine diet (a large number of meat, seafood), obesity, hypertension, hyperlipidemia, insulin resistance are closely related to hyperuricemia and gout. In addition, some drugs such as diuretics, vitamin B1, insulin, penicillin, cyclosporine, low-dose aspirin can also induce gout.
Gout: Acute arthritis, gout stone, chronic arthritis, joint deformity, chronic interstitial nephritis and uric acid urinary calculi occur on the basis of hyperuricemia. The most common clinical manifestation is recurrent acute monoarthritis. Therefore, asymptomatic hyperuricemia is not equal to gout. Only some patients with hyperuricemia (5% - 12%) eventually develop gout. Gout is based on hyperuricemia and has related symptoms. Gouty arthritis is the most common and initial clinical manifestation of gout. Acute episodes, single and asymmetric joint pain and swelling were mainly caused by alcohol, high purine diet, fatigue, surgery, trauma and drugs. The first metatarsophalangeal joint was the most common cause, which could be relieved by itself in a few days, and the interval was normal. Repeated attacks of gouty arthritis can affect joint function, cause major joint involvement, gradually develop into joint effusion, and gradually lead to joint deformity.
Acute stage of gout attack: acute gouty arthritis. Laboratory tests often indicate a marked increase in serum uric acid. But not all acute episodes have elevated serum uric acid.
Intermittent period of gout attack: The stage after the attack of acute gouty arthritis is only characterized by increased serum uric acid concentration. Most of them are 1-2 years after acute attack, but the individual difference is great, and the interval time is shorter and shorter as the disease progresses.
Chronic gout stage: The formation of gout stone is the manifestation of gout entering the chronic