Hello, do you have any medicine for fibromyalgia now? Does the medication in use alleviate your situation? In the treatment of fibromyalgia, some antidepressants and several antiepileptic drugs are the most well studied and uniformly effective drugs. Antidepressants include tricyclic drugs (such as amitriptyline) and several selective serotonin and norepinephrine reuptake inhibitors (SNRIs), including duloxetine and minoprilone. Antiepileptic drugs beneficial to fibromyalgia include gabapentin and pregabalin. In the initial treatment, we usually use a tricyclic drug. In patients with insufficient response or intolerance, we use an SNRI or an antiepileptic drug instead. For patients with more severe fatigue or depression, or with more severe sleep disorders, an alternative initial treatment is either an SNRI or an antiepileptic drug. For example, the initial choice of amitriptyline, if the treatment of amitriptyline ineffective or intolerant patients, as well as patients with severe fatigue or in addition to pain also need to use medication for depression, it is recommended to use Duloxetine instead of amitriptyline for treatment. Pregabalin is recommended for patients who are ineffective or intolerant of amitriptyline treatment, as well as those with more severe sleep disorders besides pain. These two are not commonly used together, so amitriptyline can be preferred.