Oral lesion is common with lupus, mostly as in ulcers. This requires a biopsy to confirm. An oral lesion linked to lupus may be caused by active disease, or drugs treating lupus. A biopsy will let you know if it's an active disease. Drugs that may lead to oral lesion incl. NSAIDs, COX2 inhibitor, antimalarial drugs, immunosuppressive drugsprednisone, rituxan.