Sickle cell disease (SCD) is a group of inherited red blood cell disorders. The sickle-shaped cells are not flexible and cannot change shape easily. Many of them burst apart as they move through your blood vessels which can lead to intravascular hemolysis and increased iron levels. Your body may have trouble making enough new cells to replace the ones that you lost. Because of this, you may not have enough red blood cells. This is a condition called anemia, and it can make you feel tired. The treatment for sickle cell anemia is usually aimed at avoiding crises, relieving symptoms and preventing complications, include medications to reduce pain and prevent complications, and blood transfusions, as well as a bone marrow transplant.