Hashimoto's thy roiditis, or chronic lymphocytic thy roiditis, is an autoimmune disease. Also known as Hashimoto's disease or Hashimoto's thyroiditis, and autoimmune thyroiditis, also known as autoimmune thyroiditis, this disease is more common in middle-aged women, there is a tendency to develop into hypothyroidism, clinical more common. Most of them are women aged 30 to 50 years old. The onset of the disease is concealed and the course of the disease is slow. The main manifestation is goiter. Most of them are diffuse. A few can be limited. Some of them are caused by swelling of the face and limbs.
1. Autoantibodies with high titers against various components of thyroid can be detected in the serum of patients during the course of disease. For example, thyroid microsomal antibody, thyroglobulin antibody and serum thyroxine stimulation blocking antibody (TsBAb) increased in some patients.
2. Evidence of cellular immunity is that there are a large number of plasma cells and lymphocyte infiltration and lymphoid follicles in thyroid tissue. T lymphocyte is sensitized by Blastcell formation, migration inhibitor and lymphotoxin production, and the corresponding antigen is mainly thyroid cell membrane.
3. Some patients are accompanied by other autoimmune diseases such as pernicious anemia, disseminated erythema, rheumatoid arthritis, Sjogren's syndrome, type I diabetes mellitus, chronic active hepatitis, etc. When the thyroid function is obviously low in the later stage of the disease, it presents mucoedema clinically. Inhibitory T lymphocyte genetic defects in patients lead to the production of thyroid autoantibodies. In combination with this disease, K cells mediate immunity, releasing soluble cells including lymphotoxins, leading to thyroid cell damage. In addition, genetic factors are closely related to the pathogenesis of autoimmunity. Family clustering is common in this disease, and it occurs more frequently in females. In the study of HLA genetic factors, we found that DBW3 and DR5 were increased in