Total knee arthroplasty (TKA) has a strong postoperative pain response. Postoperative pain will not only affect patient satisfaction and postoperative joint function recovery, but also lead to an increase in the incidence of complications. Epidural analgesia and femoral nerve block (FNB). For TKA, FNB is the preferred method, but may have insufficient analgesia. If the analgesia is insufficient, additional sciatic nerve block seems to be a reasonable choice; however, the advantages of conventional sciatic nerve block have not been fully demonstrated. A single block usually provides adequate analgesia for the first 24 hours; continuous FNB prolongs the analgesia time to promote functional recovery. For muscle strength reduction, by adjusting the infusion rate and local anesthetic dose, muscle strength can be reduced and the risk of falling can be reduced. Compared with regional analgesia (such as FNB), epidural analgesia has no advantage in knee surgery. Lumbar epidural analgesia risk is greater than Benefits, and peripheral nerve block can provide similar analgesic effects. Large-volume local injection analgesia has a low incidence of adverse events and less motor block, which may be a promising technique for postoperative analgesia after TKA. However, the formulation and capacity of analgesics remains to be further studied.