What Are the Symptoms of Multiple System Atrophy?

4 Answers

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Is it possible to have MSA-P & C?  My husband has a little of both but more C where his movement issues, speech unable to control bowels and swallowing.  But, he has the tremors & slow movement. Do you classify him as MSA- C being he exhibits more of those symptoms?  Thanks
I think it's not important. does the doctor give therapy. I think there is no difference in therapy.
My Brother n-law was diagnosed with MSA this last week! He’s been showing signs for 2 years my question is are there stages in this disease?
I don't think there's a staging for MSA, there're types, MSA P or MSA C
As the disease progresses one of three groups of symptoms predominate. These are:
1)Parkinsonism (slow, stiff movement, writing becomes small and spidery)
2)Cerebellar dysfunction (difficulty coordinating movement and balance)
3)Autonomic nervous system dysfunction (impaired automatic body functions) including: postural or orthostatic hypotension, resulting in dizziness or fainting upon standing up;urinary incontinence or urinary retention;impotence;constipation;vocal cord paralysis;dry mouth and skin;trouble regulating body temperature due to sweating deficiency in all parts of the body;loud snoring, abnormal breathing or inspiratory stridor during sleep; other sleep disorders including sleep apnea, REM behavior disorder[19]
Other symptoms such as double vision can occur. Not all patients experience all of these symptoms.
Some patients (20% in one study) experience significant cognitive impairment as a result of MSA.
Multiple system atrophy score
It mainly includes four items: history review, exercise examination, autonomic function test and overall disability score. The scores of the first and second items range from 0 (normal) to 4 (severe abnormal).
The average remaining lifespan after the onset of symptoms in patients with MSA is 6-10 years.  Approximately 60% of patients require a wheelchair within five years of onset of the motor symptoms, and few patients survive beyond 12 years. The disease progresses without remission at a variable rate - those who present at an older age, those with parkinsonian features, and those with severe autonomic dysfunction have a poorer prognosis.  Those with predominantly cerebellar features and those who display autonomic dysfunction later have a better prognosis.
My brother is diagnosed with M.S.A. he now wears a diaper. He can hardly walk. He can talk, eat, his motor skills are going. Is their a stem cell facility in the states. I would love some help, my brother is 64 years young. Thank you
Hello Ms. Packard, Mesenchymal Stem Cell Therapy in MSA is under research currently. Here are some links that you might obtain the latest information. The links are from MSA organization, Mayo and Harvard Medical School. https://www.multiplesystematrophy.org/newsletter/interview-dr-wolfgang-singer https://www.mayo.edu/research/clinical-trials/cls-20146501 https://hsci.harvard.edu/people/vikram-khurana-mb-bs-phd There're contact info in these websites. As I've checked, the clinical trial of Mayo isn't enrolling people but you can still try to contact them, research people are usually very nice and they might give you more information.
It's unknown, no one knows what exactly causes MSA.
Latest research shows it's likely linked to genetic change, but not totally inherited. Meaning that people can inherit a few high risky genes, however if the inherited gene works normally people don't get MSA. Only when the gene was somehow changed the disease occurs.
Parkinson is hereditary so if the gene is present why wouldnt MSA be hereditary?
Parkinson is not hereditary in the majority of cases. Also, MSA is not hereditary too