I've taken Pycnogenol for 4 years, I've tried 150 mg. 100 mg and 30 mg. 100 mg is the optimal for me. 30 mg is less effective but 150 mg made me sleepless. It does help in relieving pains here and there, I used to feel pain in shoulder, arm, leg, etc. I feel less pain now. I become very energetic, also I think my brain has been working faster, although I've been smart always I think Pycnogenol makes me sharp despite of age. I also tried a few other brands, and I prefer Health Origins. Reason? The best price comparing with other brands. If you search Pycnogenol 100 mg in iherb or amazon you can see many brands, if you compare you'll find Health Origins offers the best price.