Dear,according to Localized scleroderma: clinical spectrum and therapeutic update Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is confined to the skin and/or underlying tissues. Localized scleroderma is a rare disease of unknown etiology. Recent studies show that the localized form may affect internal organs and have variable morbidity. Treatment should be started very early, before complications occur due to the high morbidity of localized scleroderma. In this review, we report the most important aspects and particularities in the treatment of patients diagnosed with localized scleroderma. Plaque morphea The most frequent form of LoS in adults is the plaque morphea, which is well-circumscribed and typically confined to the dermis. It is characterized by limited, round or oval shaped areas of hard and shiny skin, and affects one or more anatomical regions, most frequently the trunk and proximal extremities (F. In the earliest phases, a characteristic violaceous halo can be seen around the plaque (\"purple ring\"); this corresponds to the inflammatory phase of morphea. Bullous morphea Bullous morphea is a rare form of morphea characterized by the appearance of bullae or erosions on morphea plaques. Deep morphea The subtype classified as \'deep morphea\'usually manifests itself as a single lesion on the upper trunk, near the spine.19,20,21 The overlying skin may have a normal appearance, an atrophic appearance or be hardened, and will almost always be depressed or adhered to the deep plane. It is usually asymptomatic and is not associated with visceral involvement. Deep morphea is usually not preceded by clinical evidence of inflammation, skin discoloration or sclerosis . Some authors conclude that PFH may
