What Causes Clostridium Difficile Colitis?

4 Answers

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So when we get sick and need antibiotics what do we do?  Whats the safest antibiotic?
To select antibiotics, u should identify the pathogen (preferably bacteriological diagnosis and drug sensitivity test in vitro), and select antibiotics with high efficacy and low toxicity. If it is difficult to determined, combination therapy or broad-spectrum antibiotics are often used. In addition, the antimicrobial activity, pharmacokinetic characteristics and adverse reactions of antimicrobial agents should be considered. Antibiotics should be avoided as far as possible in skin and mucosa, so as not to cause drug-resistant bacteria to produce or allergic reactions. Penicillin (G): is the first antibiotic found, pneumococcus, group A hemolytic streptococcus and anaerobic bacterial infection of Bacillus fragilis are still the preferred drugs. Macrolides: suitable for mild and moderate respiratory tract infection, mycoplasma and Chlamydia infection. Aminoglycosides: add 10% glucose solution 100 ml once a day, intravenous drip has good curative effect, less toxicity and is not easy to produce drug-resistant strains. It is suitable for G-bacilli infection, Staphylococcus aureus infection, etc. for about 7 days. Attention should be paid to its ototoxicity and nephrotoxicity. Quinolones: mostly suitable for urinary tract infections, intestinal infections and mild to moderate respiratory infections. Cephalosporins: In addition to the first generation, some second generation and oral preparations, generally belong to non-preferred drugs. If it belongs to moderate or severe nosocomial infection, the third generation cephalosporin can be used. If it belongs to severe nosocomial infection, severe mixed infection (aerobic and anaerobic bacteria), patients with low immune function may consider using Tylenol. So, you need to choose antibiotics according to which bacteria u r infected
To select antibiotics, u should identify the pathogen (preferably bacteriological diagnosis and drug sensitivity test in vitro), and select antibiotics with high efficacy and low toxicity. If it is difficult to determined, combination therapy or broad-spectrum antibiotics are often used. In addition, the antimicrobial activity, pharmacokinetic characteristics and adverse reactions of antimicrobial agents should be considered. Antibiotics should be avoided as far as possible in skin and mucosa, so as not to cause drug-resistant bacteria to produce or allergic reactions. Penicillin (G): is the first antibiotic found, pneumococcus, group A hemolytic streptococcus and anaerobic bacterial infection of Bacillus fragilis are still the preferred drugs. Macrolides: suitable for mild and moderate respiratory tract infection, mycoplasma and Chlamydia infection. Aminoglycosides: add 10% glucose solution 100 ml once a day, intravenous drip has good curative effect, less toxicity and is not easy to produce drug-resistant strains. It is suitable for G-bacilli infection, Staphylococcus aureus infection, etc. for about 7 days. Attention should be paid to its ototoxicity and nephrotoxicity. Quinolones: mostly suitable for urinary tract infections, intestinal infections and mild to moderate respiratory infections. Cephalosporins: In addition to the first generation, some second generation and oral preparations, generally belong to non-preferred drugs. If it belongs to moderate or severe nosocomial infection, the third generation cephalosporin can be used. If it belongs to severe nosocomial infection, severe mixed infection (aerobic and anaerobic bacteria), patients with low immune function may consider using Tylenol. So, you need to choose antibiotics according to which bacteria u r infected
Thank you very much
does it matter which antibiotic is causing C-difficile? Or can any antibiotic cause this?
Hi Frank, it doesn't matter which antibiotic it is, it does matter how long a person has been using antibiotics. When a person takes antibiotics, good germs that protect against infection are destroyed for several months. During this time, patients can get sick from C. difficile picked up from contaminated surfaces or spread from a health care provider’s hands. Those most at risk are people, especially older adults, who take antibiotics and also get medical care.
How is it treated?
Antibiotics. For mild to moderate infection, doctors usually prescribe metronidazole (Flagyl), orally. Metronidazole is not approved by the FDA for C. difficile infection, but has been shown to be effective in mild to moderate infection. For more severe and recurrent cases, vancomycin (Vancocin), also taken by mouth, may be prescribed. Another oral antibiotic, fidaxomicin (Dificid), has been approved to treat C. difficile. In one study, the recurrence rate of C. difficile in people who took fidaxomicin was lower than among those who took vancomycin. However, fidaxomicin costs considerably more than metronidazole and vancomycin.
Once you had c diff, are you pron to get it again
No. c. diff infection can be treated and there is no tendency to get reinfection.
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