A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe. Studies indicate a 34% to 51% genetic influence of likelihood to develop migraine headaches. Migraines may be induced by triggers. any things such as fatigue, certain foods, and weather have been labeled as triggers; however, the strength and significance of these relationships are uncertain. Enlarged heart seems not related to migraine. If you worry about the enlarged heart a lot, the anxious feeling can be a serious trigger. Try to relax and see.