In a healthy individual, the total kappa to lambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm.
There are no international reference products for free light chain, and the detection methods are not uniform. Therefore, the test results of different manufacturers' kits are incomparable.
Low kappa light chain is not related to disease. if it is high , you should see a Hematologist.