C-reactive protein (CRP) is a sharply elevated protein (acute protein) in the plasma when the body is infected or damaged by tissue. It activates complement and strengthens the phagocytosis of phagocytic cells to regulate and remove the invading organism. Pathogenic microorganisms and damaged, necrotic, and apoptotic tissue cells.
It plays an important protective role in the body's natural immunity process. There have been more than 70 years of research on CRP. Traditionally, CRP is a non-specific inflammatory marker, but nearly a decade of research has revealed that CRP is directly involved in cardiovascular diseases such as inflammation and atherosclerosis. The most powerful predictor and risk factor for cardiovascular disease. CRP is the first protein that is considered to be an acute phase response, which is normally present in very small amounts and has a sharp increase in blood levels during acute trauma and infection. CRP is the most commonly used indicator of acute phase response in the clinic. As a very sensitive indicator of acute phase response, plasma CRP concentration rapidly increased significantly in acute myocardial infarction, trauma, infection, inflammation, surgery, and tumor infiltration, up to 2000 times normal. Combined with clinical history, it helps to follow up the course of the disease. Especially in the process of inflammation, follow-up rheumatism, systemic lupus erythematosus, leukemia and so on.
Elevation is common in:
(1) Acute inflammation or tissue necrosis, such as severe trauma, surgery, acute infection, etc.: CRP often rises sharply within a few hours, and rises before erythrocyte sedimentation rate increases. CRP also returns to normal before erythrocyte sedimentation. The CRP concentration of the operator decreased 7-10 days after surgery, otherwise it may indicate infection or complicated thrombosis;
(2) Acute myocardial infarction: increased 24-48h, decreased after 3 days, returned to normal after 1-2 weeks;
(3) acute rheumatic fever, rheumatoid arthritis, systemic lu