effexor® Sustained Release Capsules should be taken at the same time in the morning or evening at a fixed time, once daily. Capsules should be taken as a whole to avoid separation, crushing, chewing or dissolving. Alternatively, the capsules can be carefully opened to place the contents in a spoonful of apple sauce. The mixture of the drug/food should be swallowed without chewing and then drunk. A glass of water is guaranteed to be completely taken.