Hello Lew. Sitting in a soiled diaper too long before it is changed might get you into infection, but not necessarily sepsis. An infection occurs when bacteria enter one's body, multiply and cause illness. If that infection isn’t stopped, it can cause a life-threatening condition called SEPSIS. Sepsis is often linked to infection of lungs (pneumonia), kidney (urinary tract infection), skin and gut. So any environment factors that might cause infection in lung, kidney, skin and gut are no good. However, the most important things of prevention are managing your chronic medical conditions, guarding your immune system by eating well and exercising regularly, practicing good hygiene, such as handwashing, and keeping cuts clean until healed, and getting medical support when you're in an infection. As long as the infection is well managed, it won't develop into sepsis.