Granuloma caused by infection with biological pathogens can form cell nodules with a special structure and become infectious granuloma. Foreign body granuloma is caused by foreign bodies. The lesions are centered on foreign bodies, surrounded by a large number of macrophages, foreign giant cells, fibroblasts and lymphocytes, forming nodular lesions. Non-necrotic epithelioid cell granuloma that occurs during sarcoidosis is called sarcoidosis granuloma. In tuberculosis, caseous necrosis can be calcified.