What are the causes of nodular prurigo?

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Nodular prurigo is a skin disease that occurs on the legs, arms and even everywhere in the body. The nodules caused by nodular prurigo are pruritic or itchy. They are usually found in groups, ranging from a few to a couple of hundreds.

According to researches, the middle-aged to elderly persons are more likely to get nodular prurigo. At the same time, females are at higher risk to get this disease.

The exact causes of nodular prurigo are still unknown. The following factors are related to nodular prurigo.

  1. Fungal infections
  2. Poor diet
  3. Yeast infections
  4. Toxin
  5. Allergic disorders
  6. Poor liver function
  7. Psychiatric Illness such as delusion of parasitosis
  8. Parasites
  9. Thyroid disease
  10. Linear IgA disease (an autoimmune disease condition)
Besides, genetic factors also accelerate the development of this disease.
Prurigo nodularis (PN), also known as nodular prurigo, is a skin disease characterised by pruritic (itchy) nodules which usually appear on the arms or legs. Patients often present with multiple excoriatedlesions caused by scratching. PN is also known as Hyde prurigo nodularis, Picker's nodules, atypical nodular form of neurodermatitis circumscripta, lichen corneus obtusus. Lichen simplex chronicus is a distinct clinical entity.

The cause of prurigo nodularis is unknown, although other conditions may induce PN. PN has been linked to Becker's nevus, linear IgA disease, an autoimmune condition, liver disease and T cells. Systemic pruritushas been linked to cholestasis, thyroid disease, polycythaemia rubra vera, uraemia, Hodgkins disease, HIV and other immunodeficiency diseases. Internal malignancies, liver failure, renal failure, and psychiatric illnesses have been considered to induce PN, although more recent research has refuted a psychiatric cause for PN. Patients report an ongoing battle to distinguish themselves from those with psychiatric disorders such as delusions of parasitosis and other psychiatric conditions.