Clinical Trial – Monitoring and Treatment of Relapsed Leukemia – Leukemia

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Reuven Schore is running a clinical trial to test drugs called Bortezomib and Pravastatin to treat Leukemia. This study aims to monitor patients for relapse of the leukemia following allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in order to identify patients early in relapse, with a low burden of disease, when interventions may be more successful by monitoring of peripheral blood lineage specific chimerism. Once disease has been confirmed, patients will initiate a novel combination of bortezomib and pravastatin. The drugs are Bortezomib and Pravastatin.
Study Type : Interventional (Clinical Trial)
Estimated Enrollment : 50 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Pilot Study to Evaluate the Tolerability of Velcade (Bortezomib) and Pravastatin for the Treatment of Relapsed Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation in Children
Actual Study Start Date : May 2015
Estimated Primary Completion Date : July 2019
Estimated Study Completion Date : August 2020
Contacts
Contact: Maggie Holly 202-476-5532 mholly@childrensnational.org
Contact: Reuven Schore, MD 202-476-5875 rschore@childrensnational.org
NCT Number
NCT number: NCT02484261
For enrollment please visit www.clinicaltrials.gov.
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