What Is the Best Medication For Narcolepsy?

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Since there is no cure for narcolepsy, the only thing we can do is to manage the symptoms. Medications for narcolepsy include:
  • Stimulants, which help people with narcolepsy stay awake during the day by stimulating the central nervous system. Modafinil (Provigil) or armodafinil (Nuvigil) might be tried first.
  • Selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs) which help alleviate the symptoms of cataplexy, hypnagogic hallucinations and sleep paralysis by suppressing REM sleep. Fluoxetine (Prozac, Sarafem, Selfemra) and venlafaxine (Effexor XR) are included.
  • Tricyclic antidepressants which are effective for cataplexy including protriptyline (Vivactil), imipramine (Tofranil) and clomipramine (Anafranil).
  • Sodium oxybate (Xyrem) which helps to improve nighttime sleep. In high doses it may also help control daytime sleepiness. Be sure not to take it with other sleeping medications, narcotic pain relievers or alcohol because it may lead to difficulty breathing, coma and death.
You should consult with your doctor before taking the medications to find out which one is the best for you.   Keywords: best medication narcolepsy
Provigil works great for the fatigue. Nuvigil is newer but does not work anywhere near as well in my opinion.