What Medications Are Used to Treat IBS-C?

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The common medications used for IBS-C include:
  • Linaclotide (Linzess)
People age 17 or younger shouldn’t take it. The most common side effect is diarrhea.
  • Lubiprostone (Amitiza)
It treats IBS-C in women who haven’t been helped by other treatments. Studies haven't fully shown that it works well in men. Common side effects include nausea, diarrhea, and belly pain.
  • Plecanatide (Trulance)
It is a prescription medication that has been shown to treat constipation without the usual side effects of cramping and abdominal pain.
  • Antidepressants
Anti-depressants can block the brain's perception of pain in the gut. For IBS-C, your doctor may prescribe small doses of an SSRI (selective serotonin reuptake inhibitor) antidepressant, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft). Their side effects may include nausea, loss of appetite, and diarrhea.   Keywords: medications IBS-C; IBS-C medications; IBS constipation medications.