Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH.
The disease results from the abnormal function of the pituitary gland, the hypothalamus, or both. Moreover, central hypothyroidism can be isolated or combined with other pituitary hormone deficiencies, which are mostly acquired and are rarely congenital.
Patients with signs and symptoms of hypothyroidism, recurrent headaches or visual field defects, as well as concomitant or pre-existing hypothalamic or pituitary disorders, should be investigated for central hypothyroidism.
Key word: central hypothyroidism