PLS cannot be prevented, stopped or reversed for now. So when we talk about the treatments for PLS, mainly we're trying to relieve symptoms and preserve function.
Here are some common treatments, include:
Oral medication such as baclofen, tizanidine or clonazepam are common medications prescribed by your doctors for relieve muscle spasms. If it doesn't work, your doctor may recommend an intrathecal baclofen. For those with depression problems, antidepressants are helpful. For those with drooling problems, you can take a try with amitriptyline and other drugs.
Exercises like stretching and strengthening are good for your muscle strength, flexibility and range of motions. Besides, it's beneficial for joint immobility. If your muscle pain is severe, heating pads can also be helpful.
Speech therapy would be helpful if you have speech and facial muscle problems.
Assistive devices such as a cane, walker or wheelchair may become necessary as PLS progresses.