What’s the Connection Between Tree-in-Bud Sign and Lung Disease?

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Tree-in-bud sign is a description of certain CT scan result. As the centrilobular bronchial dilatation and filling by mucus, pus or fluids looks like a budding tree, the pattern is called tree-in-bud. The presence of tree-in-bud indicates lung diseases, especially bronchial disorders. These lung diseases include:
  • Infections.
  • Congenital disorders: such as cystic fibrosis.
  • Idiopathic disorders: obliterative bronchiolitis, diffuse panbronchiolitis, etc.
  • Aspiration or inhalation of foreign substances.
  • Immunologic disorders.
  • Peripheral pulmonary vascular disease.
Of course, a tree-in-bud sign also suggests other conditions (for instance, rheumatoid arthritis).   Keywords: tree-in-bud; lung disease; bronchial disorder.