What Is the Autoimmune Mechanism of Dermatomyositis?

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Dermatomyositis is an autoimmune disease predominantly affecting skin and muscle. Its poorly understood pathogenesis is increasingly being linked to the overproduction of type 1 interferon-inducible gene transcripts and proteins. Type 1 interferon (IFN)-inducible genes and their inducible products are upregulated in dermatomyositis muscle. Among which IFN-stimulated gene 15 (ISG15) is one of the most upregulated, suggesting its possible involvement in the pathogenesis of this disease. But studies provide evidence that ISG15, which is highly upregulated in dermatomyositis muscle, does not appear to play a key role in IFN-beta-mediated C2C12 myoblast cell fusion.   Keywords: autoimmune dermatomyositis; autoimmune disease dermatomyositis; dermatomyositis autoimmune.