What Are the Basics of Granulomatosis with Polyangiitis?

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Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a systemic vasculitis that typically involves small and medium vessels. Other organs or regions that may be targeted include:
  • upper and lower respiratory tract
  • pauci-immune glomerulonephritis
  • cutaneous
  • ocular
  • musculoskeletal
  • peripheral nervous system tissue
GPA is an autoimmune disorder occurs when the healthy body tissue is attacked and destroyed by the body’s immune system accidentally. Signs and symptoms of GPA may include:
  • sinus pain and inflammation
  • unny nose, with pus-filled discharge
  • nosebleeds
  • fever
  • general ill feeling (malaise)
  • unintended weight loss
  • ear infections
  • cough
  • chest pain
  • coughing up blood
  • shortness of breath
  • joint aches and swelling
  • blood in urine
  • skin sores
  • eye redness, burning or pain
Tests required to diagnose GPA are as follows:
  • ANCA: antineutrophil cytoplasmic antibodies, a blood test looks for proteins
  • Urinalysis: for detecting signs of kidney disease
  • Biopsy
There are also other tests that may be performed based on your symptoms, please consult your doctor for details. Keyword: granulomatosis with polyangiitis.