Chronic eosinophilic leukemia (CEL) is a rare type of myeloproliferative neoplasm. In CEL, too many eosinophils, a type of white blood cells to defend against infections and allergy, are produced in the bone marrow. A large number of these cells can be seen in the blood, the bone marrow and other tissues.
The etiology of CEL remains unknown. It is not caused by a certain abnormal chromosome or gene. However, some breakthroughs have been made. CEL is generally caused by overactivation of the oncogene. In most cases, CEL progresses slowly and can remain the same for many years. However, it can also get worse quickly and turn into acute myelogenous leukemia (AML).
Although it is a rare disease, it responds positively to treatments, such as Gleevec.
Keywords: chronic eosinophilic leukemia