What is the cause of high protein in your blood?

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Is it a high albumin in your blood? There are many causes for the low albumin level, but there are only a few causes for a high albumin level.

The potential causes for a high albumin level include:

  • Dehydration.
  • HIV AIDS.
  • Monoclonal gammopathy of undetermined significance (MSG).
  • Multiple myeloma.
  • Amyloidosis.
  • Chronic inflammatory conditions.
  • Bone marrow disorder. 

It may be a sign of an underlying disease.

Causes of high blood protein levels, including:

  • Complete Breakdown of Immune System
  • Waldenstrom's Disease
  • Multiple Myeloma
  • Amyloidosis 
  • Monoclonal gammopathy of undetermined significance (MGUS)


If you notice constant fever, excessive fatigue, unexplained weight loss, nausea and loss of appetite, then you should immediately see your doctor. You should undergo the tests suggested by your doctor. A total serum protein test is generally performed to assess liver and kidney function. It is also ordered to find out the cause of swelling of the ankles (edema) or abdomen (ascites) or of fluid collection in the lungs leading to shortness of breath (pulmonary edema), etc. The test also helps determine whether your diet contains enough proteins. Doctors may order several other tests to diagnose multiple myeloma or Waldenstrom's macroglobulinemia. Depending upon the underlying cause, the doctor would design the treatment to lower blood protein levels.

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