My husband had his removed three weeks ago, his platelets are 542. Is he in danger?

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3 Answers

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What has been removed?
Increased platelets are extremely common in patients with splenectomy (removal of the spleen), because the spleen destroys the platelets. Although theoretically increased platelet number would increase the risk of thromboembolism, it is not common. Your doctor probably would recommend you take aspirin daily to control this risk.

The normal range for platelet count is 150,000 to 400,000 platelets per microliter (mcL) or 150 to 400 × 109/L. A level of 542 × 109/L is high—and it's called thrombocytosis.

Causes of thrombocytosis may include:

  • A type of anemia in which red blood cells in the blood are destroyed earlier than normal (hemolytic anemia)
  • Iron deficiency
  • After certain infections, major surgery or trauma
  • Cancer
  • Certain medicines
  • Bone marrow disease called myeloproliferative neoplasm (which includes polycythemia vera)
  • Spleen removal

Some people with high platelet counts may be at risk of forming blood clots or even bleeding too much.

Did your husband have the spleen removed 3 weeks ago?