Aged Brain Cells Can Be Young Again? Successful Experiment in Mice

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Some of you may know a movie called "The Curious Case of Benjamin Button". It is about a man who ages in reverse. But can people in reality reverse their aging process? Unbelievable as it may sound, yet it can happen in brain stem cells in mice.

    

    

Mysterious brain stem cells

    

A multi-disciplinary research team, based at the Wellcome-MRC Cambridge Stem Cell Institute (University of Cambridge), studied young and old rat brains and found that a type of brain stem cell would have lower function as the brain became stiff and aged.

    

These cells are called oligodendrocyte progenitor cells (OPCs), which are important for maintaining normal brain function, and for the regeneration of myelin—the fatty substance that surrounds our nerves. Myelin can be affected during the aging process and cause multiple sclerosis (MS), an often-disabling disease of the central nervous system.

    

    

Aged brain stem cells can become young again

    

As brain ages, the brain becomes stiffer and harder. But when the researchers transplanted older OPCs from aged rats into the soft brains of younger rats, the older brain cells were rejuvenated remarkably, and began to behave like the younger, more vigorous cells.

    

To study this further, the researchers developed new materials in the lab with varying degrees of stiffness. They also investigated Piezo1—a protein found on the cell surface, which informs the cell whether the surrounding environment is soft or stiff.

    

It turned out that when rat brain stem cells were on the stiff material, the cells became dysfunctional and lost their ability to regenerate, and in fact began to function like aged cells. What was especially interesting was that when the old brain cells were on the soft material, they began to function like young cells—in other words, they were rejuvenated.

    

    

The remarkable meaning for humans

    

When we age, our muscles and joints may become stiff, making everyday movements more and more difficult. This study shows that it is also true in our brains. In addition, it demonstrates new ways to reverse older stem cells to a younger and healthier state.

    

These above results have far reaching implications for how we understand the aging process, and how we might develop treatments for age-related brain diseases such as multiple sclerosis (MS).

    

What is multiple sclerosis (MS) in detail?

    

    

MS is a condition that can affect the brain and spinal cord when the immune system attacks the protective myelin in the aging process. Eventually, the disease can cause permanent damage or deterioration of the nerves.

    

To know the early signs and symptoms of MC, you can check: What Are Early Symptoms of Multiple Sclerosis? 

    

        

For now, there is no cure for MC. People who have mild symptoms sometimes do not need treatment. And there are treatment options that can help accelerate the recovery, slow the progression of the disease and manage symptoms. Treatments may include:

    

—Short courses of steroid medicine to speed up recovery

—Specific treatment plan for specific symptoms

—Disease-modifying therapies to reduce the number of relapses

    

 

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2 Answers

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curlingtoes and Hands
I am a 51 year old female that just found out I have Motor Neuron Disease Parkinson's about a year and half, but I have been having signs of it for years, tremors, depression, body weakness. ECT. I honestly don't think my doctor was reading the signs because of my gender and age. A few years ago I had my shoulder lock up on me and I was sent to a P.T since x-rays didn't show any physical damage. My shaking was getting worse and I began falling. Only when my speech became so bad that it brought concern to my dentist was Parkinson's even considered. He phoned my doctor with his concerns about my shaking and balance problems. By this time I was forgoing shots in the back of my neck for back and neck pain to which once again I was sent to a P.T (although x-rays showed no damage) I was told I had a few spurs which were most likely causing the pain. Here I was feeling like my whole body was falling apart and doctor could not find anything wrong, maybe in was all in my head? My doctor even seemed annoyed with me and things just kept progressing and I just kept it to myself, why bother going through testing and them finding nothing? Well, it was after my second P.T called my doctor about the weakness in my legs and arms, by this time I have developed a gait in my walk and I fell more frequently. Only then did my doctor send me to a specialist and it was found that I had Parkinson's, and that I have had it for awhile. I think because I was a woman that my signs and symptoms weren't taken seriously and therefor left untreated for so long,I was taking pramipexole dihydrochloride three times daily, I Was on carbidopa levodopa but only lasted 90 minutes then wore off.I found that none of the current medications worked effective for me.I got tired of using those medication so I decided to apply natural herbs formula that was prescribed to me by my second P.T, i purchase the herbal formula from totalcureherbsfoundation. com, There has been huge progression ever since I start the treatment plan which will last for 15 weeks usage.all the symptoms and sign has begin to disappear .
Ms.benita,
Please contact me at 915-204 9800.  I am a parkinsons sufferer  and would like to know more regarding the remedy you have used.  This is my wifes cell phone.
Thanks,
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