No, they are totally different things. Pick’s disease is a rare type of age-related dementia that affects the frontal lobes of the brain and causes speech problems like aphasia, behavior difficulties and eventually death. While Niemann-Pick disease is a rare, inherited disease that causes the body unable to metabolize fat (cholesterol and lipids) within cells. These cells malfunction and, over time, die. Niemann-Pick disease can have an impact on your nerves, brain, spleen, liver, bone marrow and, in severe cases, lungs. There are three types of this disease, type A and B, and Type C.